Moushumi Kuvawala & Sneha Krishna: The role of collagen in myofascial mechanotransduction
Fibroblast migration is critical to maintain homeostasis and a healthy functioning of muscular tissue. The micro-environment/ ECM of the intramuscular connective tissue (IMCT) provides structural integrity, tissue boundaries & initiates mechano-sensitive signalling pathways within the attached fibroblasts, which then influences its migration and other biochemical processes (Mechanotransduction). Stiffness of the IMCT is determined by the…